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How to edit a config in about:config via command line WITHOUT having to restart Firefox to have it applied?

I’m trying to automate a process and want to edit a config in about:config via command line WITHOUT having to restart Firefox to have it applied. How can I do that?

I’m under Linux. I tried editing the file /home/user/.mozilla/firefox/id.default/prefs.js but obviously the settings are not applied in real time but a restart is needed.