Zend certified PHP/Magento developer

Questions about backing up data?

I have installed a 3TB internal HDD, I have almost more than 2TB of personal data, this drive will be unplugged after backing up.

My question is that I have music production and photography data with millions of files, I want to ask if is it a good option to use different folders with large amounts of data as ISO image files to save a large number of files from getting corrupted.