Windows 10 AppData directory seems to overflow or corrupt, which corrupts browser extensions and other software

I recently briefly changed my temp directory in an attempt to fix a problem with Python and Anaconda, but it’s back to the default now. That may or may not be related to this problem. This happens every once in a while. Wox and Obsidian need to be reinstalled, because their executables are located in AppDataLocal (%temp%). Same with Brave’s (Chrome-based) extensions, which prompt me to “repair now”. Sometimes, after a while, they just come back on their own. C: has 73 gigabytes of storage available.